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Month: July 2018

NLM Technical Bulletin, Jul-Aug 2018, MEDLINE Milestone: 25 Millionth Journal Citation

Table of Contents: 2018 JULY–AUGUST No. 423
MEDLINE Milestone: 25 Millionth Journal Citation. NLM Tech Bull. 2018 Jul-Aug;(423):b5.
2018 July 10 [posted]
On June 22, 2018, MEDLINE attained a major milestone when the 25 millionth journal citation was added to the database. This count includes citations created from the OLDMEDLINE project.
This PubMed search retrieves the running count for MEDLINE, which is currently over 25 million citations:
medline [sb]
This PubMed search retrieves the running count for MEDLINE minus the OLDMEDLINE subset, which is currently over 23 million citations:
medline [sb] NOT jsubsetom

LL’S Magnetic Clay Inc. Expands Allergy Alert On Undeclared Allergens In Prescript-Assist Dietary Supplement To All Lots

LL’s Magnetic Clay, Inc. of Austin, Texas is recalling all lots of Prescript-Assist (still within expiration date), a dietary supplement it marketed until late 2017, because of its potential to contain undeclared allergens, including almonds, crustaceans, milk, casein, eggs, & peanuts. People who have an allergy or severe sensitivity to these specific types of allergens run the risk of serious or life-threatening allergic reaction if they consume these products.
Prescript-Assist dietary supplement was distributed nationwide, including through online sales on the LL’s Magnetic Clay website and brick & mortar retailers. The Prescript-Assist product is available through distributors other than LL’s Magnetic Clay that purchased the product from the same source.
All lots sold between 1/29/2015 – 12/31/2017 are potentially impacted. The white bottles contain capsules in quantities of either 60 or 90 capsules per bottle. A representative label is included below.
No illnesses regarding these products have been reported to date.
The recall was initiated after potential cGMP failures in the supply chain were identified by LL’s Magnetic Clay.
Consumers who have purchased Prescript Assist from LL’s Magnetic Clay are urged to discontinue use & return it to LL’s Magnetic Clay for a full refund. Consumers with questions may contact the company M-F, 9am-5pm at 1-800-257-3315.
Link to Original Recall
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Genetics Home Reference: microcephaly, seizures, & developmental delay

Dumitrache LC, McKinnon PJ. Polynucleotide kinase-phosphatase (PNKP) mutations & neurologic disease. Mech Ageing Dev. 2017 Jan;161(Pt A):121-129. doi: 10.1016/j.mad.2016.04.009. Epub 2016 Apr 26. Review.
Poulton C, Oegema R, Heijsman D, Hoogeboom J, Schot R, Stroink H, Willemsen MA, Verheijen FW, van de Spek P, Kremer A, Mancini GM. Progressive cerebellar atrophy & polyneuropathy: expanding the spectrum of PNKP mutations. Neurogenetics. 2013 Feb;14(1):43-51. doi: 10.1007/s10048-012-0351-8. Epub 2012 Dec 9.

Reynolds JJ, Walker AK, Gilmore EC, Walsh CA, Caldecott KW. Impact of PNKP mutations associated with microcephaly, seizures & developmental delay on enzyme activity & DNA strand break repair. Nucleic Acids Res. 2012 Aug;40(14):6608-19. doi: 10.1093/nar/gks318. Epub 2012 Apr 15.

Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, Caldecott KW, Barkovich AJ, Walsh CA. Mutations in PNKP cause microcephaly, seizures & defects in DNA repair. Nat Genet. 2010 Mar;42(3):245-9. doi: 10.1038/ng.526. Epub 2010 Jan 31.

Shimada M, Dumitrache LC, Russell HR, McKinnon PJ. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability. EMBO J. 2015 Oct 1;34(19):2465-80. doi: 10.15252/embj.201591363. Epub 2015 Aug 19.

Weinfeld M, Mani RS, Abdou I will will, Aceytuno RD, Glover JN. Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair. Trends Biochem Sci. 2011 May;36(5):262-71. doi: 10.1016/j.tibs.2011.01.006. Epub 2011 Feb 25. Review. …

Preparing for Menopause: A Woman's Midlife Change

July 2018
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A Woman’s Midlife Change During midlife, a woman’s menstrual periods grow further and further apart. At some point, they stop completely, & she can no longer get pregnant.
This is because the ovaries aren’t releasing eggs & making hormonesSubstances sent through the bloodstream to signal another part of the body to grow or react a certain way. like estrogen anymore. After 12 months without a period, a woman can say she’s gone through menopause.
In the years before menopause, women may experience skipped and unpredictable menstrual periods. This phase is called the midlife transition, perimenopause, or the change of life. Some women go through the transition faster than other people. It lasts between 1 & 10 years.
Midlife Transition
Typically, menopause occurs between ages 45 & 55. This means women can expect less frequent periods & other symptoms at some point during their 40s. But it’s different for every woman. There’s no lab test to predict when in life it will start or how easy it will be.
Along with unpredictable periods, a woman may have other symptoms—both physical & emotional. Hot flashes, poor sleep, & mood changes are common. Some women have vaginal dryness, weight gain, and thinning hair. Bone density may also start to decrease.
“Most people don’t have severe symptoms. Most people have mild or less frequent symptoms,” says Dr. Hadine Joffe, an NIH-supported menopause researcher and psychiatrist at Brigham & Women’s Hospital.
NIH is funding studies looking into how to relieve menopause symptoms. There are medicines & lifestyle changes…

Eating Well May Slow Hearing Loss in Women

July 2018
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Health Capsule
Many people lose some of their hearing as they get older. Experts say that, of those over the age of 75, about half have hearing loss. Not being able to hear well can make it hard to communicate. That can affect relationships with loved ones, friends, & coworkers.
A new study shows that women who have a pattern of healthy eating have a lower risk of hearing loss than women who don’t eat well. A healthy eating pattern includes lots of vegetables, fruits, & whole grains. It limits sugar, salt, & animal fat.
The study took place between 1991 and 2013. Women taking part in the study were all professional nurses. Every 4 years, the researchers asked the women to recall what they had eaten over the past year. About 71,000 women responded to the questionnaires.
The research team also asked the women whether they had noticed a hearing problem. During the study, more than 2,000 women said they had developed moderate or worse hearing loss.
The team used the reports of food intake to group the women by diet patterns. They compared women with the healthiest pattern to those with the least healthy pattern. The women with the healthiest diet pattern were less likely to have a hearing problem.
“Interestingly, we observed that those following an overall healthy diet had a lower risk of moderate or worse hearing loss,” says researcher Dr. Sharon G. Curhan at Brigham & Women’s Hospital. “Eating well contributes to overall good health, and it…

Acne Breakouts: Controlling Problem Pimples

July 2018
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Controlling Problem Pimples Zits. Pimples. Spots. Whatever you call it, acne can cause discomfort & embarrassment. This skin condition affects most people at some point during their lives. About 4 out of every 5 people experience acne outbreaks between the ages of 11 & 30.
Acne starts in the skin’s oil glands. The hair on our bodies comes out through canals from these glands called follicles. Oil glands make oils that emerge to the skin’s surface through the follicles’ openings, or pores, along with the hairs.
Sometimes hair, oil, & dead skin cells come together to plug a follicle. The plugged pore provides the right conditions for bacteria that normally live on the skin to thrive. When the body’s immune systemThe system that protects your body from invading viruses, bacteria, & other microscopic threats. attacks the bacteria, pain & swelling can result. That’s how a pimple forms.
Doctors don’t know why only some people get acne. They do know what raises the risk for acne. Increases in certain hormonesSubstances sent through the bloodstream to signal another part of the body to grow or react a certain way. can cause oil glands to get bigger & make more oil. These hormone levels go up during puberty. Because of this, acne is most common in adolescents & young adults. Hormone changes caused by pregnancy or by starting or stopping birth control pills can also trigger acne.
But people of all ages can get acne. For most, acne goes away by the time…

Celebrating Our Nation’s Birth & What It Means for All of Us

Happy Fourth of July! It’s the perfect time to fire up the grill, go watch some fireworks, & pay tribute to the vision of all who founded the United States of America. The Fourth of July also stands as a reminder of the many new opportunities that our nation & its people continue to pursue. One of the most exciting is NIH’s All of Us Research Program, which is on the way to enrolling 1 million or more Americans from all walks of life to create a resource that will accelerate biomedical breakthroughs & transform medicine.
What exactly do I mean by “transform?” Today, most medical care is “one-size-fits-all,” not tailored to the unique needs of each individual. In order to change that situation and realize the full promise of precision medicine, researchers need a lot more information about individual differences in lifestyle, environment, & biology. To help move precision medicine research forward, our nation needs people like you to come together through the All of Us program to share information about your health, habits, & what it’s like where you live. All of your information will be protected by clear privacy and security principles.
All of Us welcomes people from across our diverse land. Enrollment in the research program is open to all, & anyone over the age of 18 who is living in the United States can join. Since full enrollment began in May, three of every four volunteers have come from groups traditionally underrepresented in biomedical research. These include people from…

May Flower International Inc. Issues a Allergy Alert on Undeclared Milk Allergens in “3+2 Soda Crackers”

May Flower International Inc. of 5672 49th Place, Maspeth, NY, is recalling its 4.4 ounce packages of “3+2 Soda Crackers” because they may contain undeclared milk allergens. Consumers who are allergic to milk allergens may run the risk of serious or life threatening allergic reactions if they consume this product.
The recalled “3+2 Soda Crackers” were distributed nationwide in retail stores. The product comes in a 4.4 oz, yellow plastic package & is un-coded.
No illnesses or allergic reactions involving this product have been reported to date.
The recall was initiated after routine sampling by New York State Department of Agriculture & Markets Food Inspectors and subsequent analysis by Food Laboratory personnel revealed the presence of undeclared milk allergens in the 4.4 oz packages of “3+2 Soda Crackers” which did not declare a milk ingredient on the label.
Consumers who have purchased 4.4 oz packages of “3+2 Soda Crackers” are urged to return them to the place of purchase for a full refund. Consumers with questions may contact the company at 1-718-366-8668.
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NLM Technical Bulletin, Jul-Aug 2018, PMC Update: Journal Selection and Participation Agreements

PMC Update: Journal Selection & Participation Agreements. NLM Tech Bull. 2018 Jul-Aug;(423):b1.
2018 July 02 [posted]
[Editor’s Note: This is a reprint of an announcement from the National Center for Biotechnology Information (NCBI). To automatically receive the latest news & announcements regarding major changes and updates to PubMed Central (PMC), please see the subscribe page.]
On June 26, 2018, PubMed Central PMC released expanded information about its selection process for journals that apply for participation. The current review process has been in place since November 2014 & focuses on the scientific rigor & editorial quality standards of each journal that applies to participate in PMC.
Some of the attributes taken into account as part of this process include the article content, journal policies, language quality, and presentation of content. The same assessment considerations are used for reevaluation of currently participating journals. We encourage you to visit the Journal Selection for PMC page to learn more.
Publishers and journals interested in submitting an application to PMC are also encouraged to review our updated policies on agreement types. These policies provide the eligibility criteria for each type of participation agreement and should be considered alongside the pre-application requirements. …

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